Circadian variation in disease activity in rheumatoid arthritis.

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چکیده

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Circadian variation in disease activity in rheumatoid arthritis.

Disease activity in rheumatoid arthritis as measured by repeated estimation of joint pain, stiffness, articular index, and grip strength was shown to have a circadian rythm, maximal activity being seen between 0200 and 0400 and minimal activity in the early afternoon. This variation in disease activity may be related to circadian alterations in immune and inflammatory responses (such as immune ...

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Disease activity in rheumatoid arthritis

4 Abbreviations 7 List of papers 9 Introduction 1. Rheumatoid arthritis 11 2. Disease activity in rheumatoid arthritis 13 3. Pro-inflammatory cytokines 15 4. Monocyte activation 18 5. Acute phase markers 21 6. Glucocorticoids 27 7. Physical disability 31 Aims of the investigation 37 Materials and methods 1. Laboratory methods 38 2. Clinical methods 39 Present investigations 44 Discussion 52 Con...

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Circadian variation in biochemical assessments used to monitor rheumatoid arthritis.

Circadian variation has been demonstrated in several clinical parameters used to assess disease activity in rheumatoid arthritis, but circadian variation in modern laboratory assessments has not been studied in depth. We therefore made 2-hourly measurements of plasma viscosity, C-reactive protein, total serum sulphydryl, and serum histidine on samples obtained over a 24-hour period from 6 patie...

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ژورنال

عنوان ژورنال: BMJ

سال: 1982

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.284.6322.1114-d